Understanding virus evolution from the host up


JT McCrone
Fred Hutch Cancer Center
Sep 09, 2025
Genome Science retreat
Islandwood, Bainbridge

"Down there with them"

Phylodynamic explorations

Exploring EBOV rate heterogeneity

Virus evolution across scales

Phylodynamics

Phylogenetics / Coalescent / Evolutionary theory

Within-host dynamcis

Virology / Bioinformatics

Within-host evolution

Standard approach

Proposed approach

Preliminary results look promising

Without error model

SARS2 within-host substitution rates very by ORF

Goal: Link to processes at global scale